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Their defining advantage over small-molecule drugs is precision
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EC 6.3.2.2) catalyst of the rate-limiting step of the -glutamylcycle leading to formation of glutathione (l--glutamyl-l-cysteinyl-glycine
The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)
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