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Potential side effects of L-carnitine supplementation include: Nausea Vomiting Stomach cramps Diarrhea A fishy body odor Muscle weakness in people with chronic kidney disease An increased risk of seizures in people with a seizure disorder Additionally, Tallent says L-carnitine supplementation may also elevate trimethylamine-N-oxide (TMAO) blood levelsa risk factor for atherosclerosis, the medical term for clogged arteries

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Dose escalation (starting low and increasing slowly) helps reduce side effects, especially nausea

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The PLS-DA score scatter plot separated the blank and HUA groups well, and component 1 explained 65.8% while component 2 explained 25.8% of the variance (Figure 4A)