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Diet, sleep, training, and stress control still do the heavy lifting

GLP-1 can also force your stomach to slow down and not allow it to empty as quickly as it normally would

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Many patients cannot tolerate the side effects, and its estimated that within a year, 80 to 90% of individuals who start on these drugs discontinue their usage

Recent research published in JMIR Formative Research (2025) showed that Second Nature participants achieved an average of 18-22% weight loss at 12 months 1, similar to the weight loss achieved in clinical trials 2

doi:10.1007/s00253-013-5074-8 Kurylenko OO, Yurkiv MT, Dmytruk KV, Sybirnyi AA (2016) Method for producing recombinant strains of methylotrophic yeast Hansenula polymorpha capable of glutathione overexpression