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Key enzymes, including erythrose-4-phosphate dehydrogenase ( Epd ), 4-phosphoerythronate dehydrogenase ( PdxB ), and 3-phosphoserine aminotransferase ( SerC ), converts erythrose-4-phosphate into 4-phosphohydroxy-l-threonine

A landmark New England Journal of Medicine study found that individuals who believed they had slow metabolisms underreported calories by 47%, even though their hormone levels and metabolic function were normal

For those with severe deficiencies, higher doses may be required initially to replenish B12 levels