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Early-phase clinical trial data, including results from a Phase 2 trial published in The New England Journal of Medicine in 2023, demonstrated substantial weight reductions in some participants exceeding 20% of body weight over 48 weeks alongside a broadly manageable short-term adverse effect profile
The lancet Diabetes & endocrinology
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A meta-analysis
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If additional glycaemic control is needed after at least another 30 days, the dose may be increased to 14 mg once daily
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