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Int J Vitam Nutr Res 1993

Last month (May 2025), Novo announced that the US Food and Drug Administration (FDA) accepted its new drug application (NDA) submission for an investigational once-daily oral formulation of Wegovy (semaglutide) for chronic weight management in adults living with obesity or overweight with one or more comorbid conditions and to reduce the risk of major adverse cardiovascular events in adults with overweight or obesity and established cardiovascular disease

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Even mild but persistent symptoms can lead to treatment discontinuation, particularly in non-diabetic individuals using these agents primarily for weight management, who may have lower thresholds for tolerability than diabetic patients

If you have genuinely exhausted optimization on tirzepatide, retatrutide (when available) offers additional receptor activation that may overcome the plateau

This is literally the same mechanism that GLP-1 medications are activating just from the other direction