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The inflammatory mechanisms that damage cells, tissues, and organs in these chronic conditions are perpetuated in part by increased oxidative stress and lowered intracellular GSH pools

10.1016/j.molcel.2018.03.029 336 TsangC

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Alpha-lipoic acid (ALA) can help restore glutathione levels if there has been a depletion due to a low immune system

Figure 13 illustrates the effects of prenatal exposure to VPA, showing that HDAC inhibition may exacerbate oxidative stress by dysregulating the expression of genes involved in the antioxidant response, thereby promoting redox imbalance through increased ROS production and impaired antioxidant defenses (Gottlicher 2001