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Allergic reactions are immune-mediated, can worsen with each exposure, and may spread beyond the application area

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An allergic reaction, by contrast, may involve itching that spreads beyond the injection site, welts or hives appearing on your arms or chest, swelling that worsens after 12 hours, or warmth and redness extending more than 2 inches from the injection point

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Theranostics 8 (4), 10591074