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Data from the EFFISAYIL program show spesolimab provides: Sustained reduction in flare frequency over 3 years ~75% of patients remaining flare-free Stable safety profile with no new signals Given the severity and unpredictability of GPP, these findings reinforce the value of targeted IL-36 inhibition for durable disease suppression

Kosiborod MN, Deanfield J, Pratley R, Borlaug BA, Butler J, Davies MJ, Emerson SS, Kahn SE, Kitzman DW, Lingvay I, Mahaffey KW, Petrie MC, Plutzky J, Rasmussen S, Rnnbck C, Shah SJ, Verma S, Weeke PE, Lincoff AM, SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM Trial Committees and Investigators (2024) Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials

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The rebound window many companies may have been counting on could narrow significantly. The categories most exposed are those driven primarily by impulse, frequency and appetite stimulation: confectionery, salty snacks, sugary beverages, certain alcohol occasions and impulse indulgent consumption, according to Tahiri