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Pancreatitis: Case studies and a few of the clinical trials on GLP-1 RAs for diabetes have raised the possibility of pancreatitis being triggered by these drugs due to the potential growth in cells in the pancreas
Liu D, Ahmet A, Ward L, et al
Damage to peripheral nerves can occur as a consequence of uncontrolled diabetes, surgical procedures and injury
Y., Ou, H
However, their signaling diverges at later stages: in the tongue, activation of these receptors produces neurotransmission and conscious taste perception, whereas in the intestine, the same receptor types modulate hormone secretion (such as GLP-1 and GIP) through endocrine signaling pathways (48, 49)
In type II diabetes, the number of docked granules is about 1/3 lower than in normal cells, and the rate of glucose-stimulated exocytosis is only 20% of that in normal cells (Kwan and Gaisano, 2005)
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