The oral tablet formulation is not yet approved in the UK
Without that signal, even with optimal protein intake, you will lose more muscle alongside fat
NICE Technology Appraisal (TA875) recommends semaglutide (Wegovy) only for adults with at least one weight-related comorbidity and a BMI 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean backgrounds)
These include: Neuroprotection : Reducing oxidative stress and inflammation that contribute to dopaminergic neuron death Mitochondrial support : Enhancing cellular energy production, which is often impaired in Parkinson's Protein clearance : Potentially improving the removal of toxic protein aggregates like alpha-synuclein Metabolic benefits : Addressing insulin resistance and glucose dysregulation, which may influence neurodegeneration However, these potential advantages must be weighed against known adverse effects of GLP-1 receptor agonists
The researchers at Sirtris are no strangers to skepticism
Brand-name semaglutide comes in manufacturer-sealed pens with built-in dose selection mechanisms