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However, if these side effects persist or become severe, patients should contact their healthcare provider for further evaluation and guidance

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TB-500 also appeared to lift expression of angiogenesis-linked factors such as VEGFA, angiopoietin-2 (Ang2), and the Tie2 receptor

FIGURE 6 5.1 In vitro tests Caudatin has been found to exhibit significant growth inhibition and induces apoptosis in a variety of cancer cell lines, such as hepatocellular carcinoma cell lines (HepG2 and SMMC-7721), breast carcinoma cell line (MCF-7) and lung carcinoma cell line (A549), with IC 50 values ranging from 3.11 to 44.68 mol/L (Fei et al., 2012b

Because there is no cure, patients must balance symptom control against the burden of side effects