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124 Nevertheless, it is crucial to emphasize that there are established nutritional recommendations for cancer care, and the weight loss or reduction in protein intake often associated with CR may conflict with these guidelines

Critical limitations include: Heterogeneity : Different strains, doses, and formulations make comparisons difficult Small effect sizes : Weight changes are typically modest and may not be clinically significant Short duration : Most studies last 12 weeks or less, providing no data on sustained effects Publication bias : Negative studies may be underreported There is no high-quality evidence that probiotic supplements can replicate the substantial weight loss achieved with prescription medications like semaglutide or tirzepatide

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Glucose metabolism may be affected, making regular blood sugar monitoring important, particularly for menopausal women already dealing with insulin resistance changes