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Such precision medicine strategies could substantially enhance GHK-Cu's therapeutic value while supporting more efficient clinical trial designs in future development programs, approaches increasingly employed across peptide therapeutic development for diverse clinical applications

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Compared with healthy controls, multiple extrathyroidal symptoms were significantly more serious in HT patients despite euthyroid status, mainly including that related to digestive system (abdominal distension, constipation and diarrhea), endocrine system (chilliness, gain weight and facial edema), neuropsychiatric system (forgetfulness, anxiety, depressed, fatigue, insomnia, irritability, and indifferent) and mucocutaneous system (dry skin, pruritus, and hair loss)

Furthermore, p62 is also an autophagy substrate, and it is used as an autophagy marker [280]

(2014) reported a 17% reduction in SRS total scores after 18-week therapy with SFN, and Ooi et al