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What is the theoretical cancer risk associated with Dihexa's mechanism
Additionally, the amenability of PLGA nanosystems to functionalization by ligands (lactoferrin) or polymers (PEG) could facilitate targeted delivery, ensuring efficient delivery of their cargos to target tissues and thus minimizing off-target effects 31
However, none of these drugs are approved for the treatment of PFIC by the European Medicines Agency (EMA) (except for UDCA, which is approved in France for the treatment of PFIC3) [14] and their efficacy is debated [1], being often unable to avoid disease progression and listing for LT [6, 8]
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