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Both are required as building blocks for glutathione

Antioxidants are substances that prevent or slow the damage that can be caused to cells by free radicals, which are also known as reactive oxygen species

Abstract Background Parkinson's disease is a neurodegenerative disorder characterized pathologically by the loss of nigrostriatal dopamine neurons that project from the substantia nigra in the midbrain to the putamen and caudate nuclei, leading to the clinical features of bradykinesia, rigidity, and rest tremor

In this context, GHK-Cu is an investigational tool to explore potential anti-fibrotic mechanisms

Tissue homogenization: Frozen tissue of brain was homogenized in 9 volumes of ice-cold tissue lysis buffer containing 150 mM sodium chloride, 1.0% NP-40, 50 mM Tris, pH 8.0 and 1 mM PMSF (phenylmethane sulfonylfluoride) with protease inhibitors (Sigma, Singapore)

doi: 10.2903/j.efsa.2020.6040 204