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Further evidence came from observations that glucose metabolism continued in tissues even in the presence of glycolysis inhibitors such as fluoride and iodoacetate ions, which inhibit enolase (EC 4.2.1.11) and glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), respectively
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This HexaPro antigen was used in a regimen termed prime and spike, in which a priming dose was administered intramuscularly to induce peripheral immune memory and a boosting dose was administered intranasally to expand and recruit spike-specific T and B cells to the mucosa [167]
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More than one-third of the cagrilintidesemaglutide group achieved a 25% or greater weight loss versus about 15% of the semaglutide alone group, and 19% achieved a 30% or greater weight loss compared with 8.7% of those on semaglutide alone
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