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14.9% mean weight loss with FDA-approved 2.4mg semaglutide over 68 weeks (directly applies to Ro-prescribed Wegovy): nejm.org/doi/full/10.1056/NEJMoa2032183 New England Journal of Medicine SURMOUNT-1 (Jastreboff et al., 2022)

PMID 16427183

Thus, we determined ER-stress response genes Xbp1 and the ER chaperone heat shock 70 kDa protein 5 (HSPA5, previously known as immunoglobulin heavy chain binding protein [BIP]), inflammation-responsive genes IL6 and IL1, and hypoxia-responsive genes hypoxia-inducible transcription factor 1 (HIF1) and GAPDH

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However, uncertainties persist regarding the prospects for adverse liver effects that might be inherent to the mechanism of action, as stabilisation of hepatic steatosis would be unwelcome

doi: 10.1002/gps.1937 23 MansurRBZugmanAAhmedJChaDSSubramaniapillaiMLeeYet al