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Likewise, the possibility of peripheral active GLP-1 going through BBB to affect the brain is negligible, even though the brain- and gut-derived GLP-1 interact with each other through a complex mechanism (53)

As a cofactor, cobalamins are essential for two cellular reactions: the mitochondrial methylmalonyl-CoA mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and the activation of methionine synthase, which is the rate-limiting step in the synthesis of methionine from homocysteine and 5-methyltetrahydrofolate