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One 2020 study found that when a GLP-1 receptor agonist was injected into specific areas of the brain in male mice, it reduced their sexual behaviors

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343 Supplementation with NAD + precursors, NR and NMN, elevated NAD + levels that can maintain the mitochondrial and metabolic functions by activating SIRT1 in mice, leading to an extensive lifespan of mice

Conclusion Fatigue on GLP-1 medications can be challenging, but it is almost always manageable