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A May 2023 letter to the editor in the research journal Acta Pharmaceutica Sinica B (APSB) discussed these issues

CJC-1295 is a GHRH analog and raises the basal GH level (trough), while Ipamorelin as a ghrelin-receptor mimetic triggers an additional, clean GH pulse

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Starting doses typically begin low and gradually increase over several weeks to minimize gastrointestinal side effects like nausea, which are the most common complaint during the first few weeks of treatment

The timeline reflects a safe, biological response rather than a harsh, immediate trauma to the tissue