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This is common and typically followed by a sudden drop (often called the "whoosh effect")

Nausea, sometimes vomiting, diarrhea, constipation

However, some users report shedding in real-world settings

The generation of the major methylated pyrrolopyrazine thione, an electrophilic intermediate species (structure 4, Figure 9), would lead to alkylation of protein thiols

Maselli, MD, ABOM, told Healthline: These medications are treatments and not curesWhile these GLP-1 medications can mute those obesity-promoting pathways or heighten obesity-fighting pathways, those pathways, fundamentally, still exist

SUPPORT Help Your Body Adapt (GLP-1 Support Pack) GLP-1 medications change how you eat and digest food