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Because ALOXs are a nonheme iron-containing enzymes, the presence of iron significantly increases their oxidative activity, and the subsequent generation of PLOOH continues to react with Fe 2+ , generating new lipid radicals
It is a well-written response, and one I highly recommend you read even if you do not read the primary paper(s)
Timing can help
Most weight loss seemed to start around 4 mg
In key secondary outcomes, tirzepatide led to a mean AHI reduction from baseline of 62.8% compared to 6.4% from baseline for placebo
Injectable semaglutide does appear to be more effective for many people
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