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The medicine is also indicated to reduce the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, according to approved labeling

Creatine raises serum creatinine levels slightly (a normal byproduct of creatine metabolism) but doesn't harm healthy kidneys in clinical studies

Furthermore, cancer cells upregulate the PPP, an early diverging branch of glycolysis, thereby promoting NADPH production and exerting antioxidant defenses [26]

Conversely, effectively reducing the RANKL/OPG ratio, increasing the expression of GPX4, and inhibiting the ferroptosis pathway can thereby treat osteoporosis (49, 50)

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