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Intrinsic factor deficiency, or "congenital pernicious anemia," is a rare autosomal recessive disorder characterized by the lack of gastric intrinsic factor in the presence of normal gastric acid secretion and mucosal cytology (ie, without gastritis) and in the absence of intrinsic factor antibodies found in the acquired form of pernicious anemia
"The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency in Helicobacter pylori -Positive Patients"
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The peptide was originally developed for obesity treatment and has been studied for its ability to stimulate fat breakdown
In some cases, the sequential use of different B12 status biomarkers or the calculation of a composite B12 status score (derived from a panel of B12 biomarkers and adjusted for folate status and age) can be used to detect deficient states that may otherwise be overlooked when using a single biomarker approach such as a B12 level (92)
