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Biomed Pharmacother Elesclomol-copper synergizes with imidazole ketone erastin by promoting cuproptosis and ferroptosis in myelodysplastic syndromes

The skin barrier prevents most applied substances from reaching deeper layers where fibroblasts reside

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doi: 10.1016/j.ccr.2014.06.025 95 BrissonLBaskiPSboarinaMDethierCDanhierPFontenilleMJet al

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When GSH levels fall below a certain threshold, GPX4 is no longer active, lipid ROS accumulate to toxic levels and cells undergo ferroptotic cell death