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Turicchi J, ODriscoll R, Finlayson G, Duarte C, Hopkins M, Martins N, et al

Jan 2024;26(1):191-200

In a hyperglycaemic state, reduced expression of T-cadherin receptors in the retinal vascular endothelium leads to APN deficiency, causing increased vascular permeability and a significant increase in VCAM-1, which damages endothelial cells [66]

That's a sub-therapeutic dose, introduced specifically to allow your body to adjust and minimise side effects

In a phase 2 clinical trial, participants receiving the 12 mg dose lost an average of 24.2% of their body weight over 48 weeks the highest weight loss ever recorded for a pharmaceutical agent in clinical trials

Cell Stem Cell 4 , 313323 (2009)