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The team made three simultaneous changes to the GLP-1 backbone: a position-8 amino acid substitution to block DPP-4 cleavage, an arginine substitution to prevent fatty-chain attachment at the wrong lysine, and attachment of a C18 fatty diacid chain via a short PEG linker at lysine-26
Gier et al (38) reported PanIN lesions located primarily in pancreatic duct glands of normal rats treated with exendin-4
What should I do if my Lipo C solution changes colour? Discard it immediately colour change from clear to yellow or amber indicates oxidative degradation of vitamin C (ascorbic acid) and glutathione, rendering the formulation therapeutically ineffective
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