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Translational perspective for the use of dual GLP-1R/GcgR agonists for obesity Multiple clinical trials involving GLP-1R/GcgR co-agonists are currently underway (Table 1)

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Dang NT, et al

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NNMT is upregulated in adipose tissue in obesity, and its inhibition is studied as a potential strategy to modulate NAD+ metabolism and metabolic gene expression