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Proper storage and handling of semaglutide are essential to maintain medication stability, efficacy, and safety

Hepatitis/Elevated liver enzymes/Jaundice Diabetic retinopathy problems: Changes in vision in those with type II diabetes, particularly vision problems may worsen in those with a history of diabetic retinopathy

And thats all before downstream purification begins, which requires its own lengthy steps, including traditional chromatography

Goals include optimizing impurity resolution, minimizing peptide carry-over, and achieving confident sequence confirmation by LC/MS

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PLoS One , 8: e65240, 2013