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We observed that L-prolinean analog of GABAwas reduced in the striatum of TS rats

This is the safest point to begin to assess tolerance and minimize the risk of side effects

Crit Rev Eukaryot Gene Expr 23:139157

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Before starting biologics or JAK inhibitors, patients require screening for tuberculosis and hepatitis B/C, and should receive appropriate vaccinations (avoiding live vaccines during treatment)

I would like to see rigorous clinical trials before approval