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Introduction Glutathione, otherwise known as the master antioxidant, has been recognized for its vast health benefits

JAK are a part of the JAK/STAT pathway, and this signaling is continuously activated, resulting in the elevated level of MMPs and apoptotic chondrocytes in RA synovial joints (130)

Within this mechanistic framework, natural compounds with antioxidant and anti-inflammatory properties, including vitamins C and E, glutathione precursors, CoQ10, L-carnosine, polyphenols including quercetin, resveratrol, and curcumin, and saffron metabolites like crocin and safranal show biological plausibility and preliminary efficacy on biochemical and behavioral endpoints

Attempts have also been made to synthesize SOD mimetics, and initial results suggest that these enzymes have therapeutic potential in asthma (83)

The results demonstrated that resveratrol administration decreased plasma levels of thyroid-stimulating hormone (TSH) as well as hypothalamic mRNA levels of thyrotropin-releasing hormone (TRH)