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In respiratory disease, cellular damage and injury is mediated by an increased oxidant burden and/or decreased antioxidant defenses

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This means that their findings may not be fully generalizable to other settings. They also note that their records only show whether a medication was dispensed to a patient and not whether they took it as prescribed

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Patients with certain medical conditions, such as endocrine neoplasia syndrome type 2 or a family history of certain types of cancers, may not be ideal candidates