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The American College of Physicians emphasizes shared decision-making in diabetes management, and intolerable side effects warrant reassessment of the treatment plan

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GLP-1 agonist medications, in turn, work by stimulating and mimicking the actions of natural GLP-1 hormones

An initial 4-8 week assessment period allows evaluation of individual response and tolerance before committing to extended therapy

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Finally, we measured exendin-4-induced mitochondrial and ER Ca 2+ responses in Control versus SPHKAP RNAi-treated WT INS-1 832/3 cells