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In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness

In addition, an increased risk of severe depressive episodes and suicidal ideation has been reported during withdrawal phases (63, 64)

Who Can Benefit From GLP-1 Therapy

Glucose-dependent insulinotropic polypeptide inhibits bone resorption in humans

Nocera et al

Erythrocytes lose K + ions through the Gardos channels, which culminates in a sharp decrease in cell volume