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Key TRIUMPH-4 Trial Results The TRIUMPH-4 study was a Phase 3, randomized, placebo-controlled trial that evaluated retatrutide in adults with obesity or overweight who also had knee osteoarthritis , a group for whom weight loss and joint stress reduction are tightly connected

Tirzepatide (Mounjaro) was the focus of this study

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The investigators administering treatments were not blinded to allocation, as daily subcutaneous dosing of semaglutide vs

In the context of Zepbound, "microdosing" refers to the practice of using doses lower than the FDA-approved starting dose of 2.5 mg weekly

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