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In the SUSTAIN 8 study, patients with T2DM exhibited a lean mass decrease of 2.3 kg alongside a total weight loss of 5.3 kg, resulting in 43.4% of weight loss attributable to lean mass, while the ratio of lean mass to total mass increased by 1.2% from the baseline [111]
Portion control became much easier, almost intuitive, which was a huge relief
But for those with severe pre-existing GERD, starting with semaglutide and its slightly gentler GI profile may be the more pragmatic choice
Many Reasons We Eat When We Are Not Hungry It doesnt take hunger for us to make appropriate eating decisions
The peptide may amplify benefits of quality sleep, while poor sleep undermines treatment efficacy
But their downsides are well-documented: high monthly costs, potential side effects such as nausea or gastrointestinal discomfort, and the need for injections
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