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Nanoparticle transport across the blood brain barrier
A recent study analysed cell-specific expression of transporters, and reported that the density of glutamate transporters is reduced in astrocytes but not in neurons [109]
Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
Types of Alopecia Areata Alopecia Areata This is the most common form, characterized by one or more round patches of hair loss on the scalp or other areas of the body
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