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Krivic A et al

The duration effect suggests GHK-Cu induces cumulative structural changes in dermal architecture where longer treatment allows more complete remodeling supporting ongoing enhanced function without continuous peptide presence

Many peptides used in cosmetic preparations act by other mechanisms to improve skin appearance or delay skin aging

Site rotation prevents localized reactions, with common areas including the abdomen (2+ inches from navel), outer thighs, and upper arms

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