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Int J Pharm: X

Interaction with melatonin : It may cause an additive sedative effect

Histidine and methionine are oxidation-prone

Kahn also calls the peptide category a bit of a gray zone, given its uncertain regulatory status, but says she wants to emphasize that patients cannot simply buy peptides from compounding pharmacies

The question isn't just "does Ipamorelin cause water retention?" but rather, "does the product I'm using contain only Ipamorelin?" With a high-quality compound, the risk of water retention is exceptionally low, allowing the true, targeted effects of the peptide to be observed

However, the relevancy of its antioxidant activity in vivo is still questionable and warrants further research (Murphy et al., 1992