A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
The GLP-1 fatigue guide and the GLP-1 headache guide provide broader context for these side effects across the entire class of incretin-based therapies, not just tirzepatide specifically
Since vitamin B12 is so vital for our proper functioning, finally absorbing enough of the vitamin will allow patients to just feel better in general as their red blood cells can get enough oxygen and the serotonin levels are elevated
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Protocols, doses, and reactions reported below come from animal research and self-reported community sources
Experts generally agree that consuming appropriate amounts of vitamin B12 is safe
