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Additionally, small-molecule inhibitors, such as retinoic acid receptor-related orphan receptor gamma-t (RORt) inhibitors (e.g., VTP-43742) and tyrosine kinase 2 (TYK2) inhibitors (e.g., deucravacitinib), are currently in development

Then, 3 days after the first dosing, the rats were exposed to a two-bottle taste preference test, that is, a voluntary choice between tap-water or the 0.1% saccharin solution

This often results in poor texture of the skin and becomes a reason behind the appearance of dryness and roughness, which leads to premature aging

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