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Generation I Semaglutide GLP-1 only Peak Weight Loss 14.9% STEP 1 trial 68 weeks Receptor Coverage Single GLP-1 FDA Status Approved (Wegovy, 2021) FIRST PUBLISHED Wilding et al., NEJM 2021 Generation II Tirzepatide GLP-1 + GIP Peak Weight Loss 22.5% SURMOUNT-1 trial 72 weeks Receptor Coverage Dual GLP-1, GIP FDA Status Approved (Zepbound, 2023) First Published Jastreboff et al., NEJM 2022 Generation III Retatrutide GLP-1 + GIP + GCGR Peak Weight Loss 24.2% Phase 2 48 weeks (highest dose) Receptor Coverage Triple GLP-1, GIP, GCGR FDA Status Phase 3 (TRIUMPH program) First Published Jastreboff et al., NEJM 2023 -SELECTED LITERATURE Key Retatrutide research and clinical publications

The STEP trial extension data showed that participants regained approximately 40 percent of lost weight within 28 weeks of stopping semaglutide

One significant action of GLP-1 agonists is to slow down how quickly food exits the stomach

Once side effects stabilize at maintenance dose (typically 812 mg weekly), you can switch to morning dosing if that fits your schedule better

El baln gstrico Spatz es un procedimiento no quirrgico que ayuda a reducir la sensacin de hambre y a controlar la ingesta de alimentos, facilitando la prdida de peso

Vanderheyden M, Bartunek J, Goethals M, Verstreken S, Lambeir AM, De Meester I, et al