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doi:10.1016/S0140-6736(21)01751-7
Benveniste MF, Rosado-de-Christenson ML, Sabloff BS, Moran CA, Swisher SG , Marom EM
AOD9604 vs Intact hGH in Obesity Models A direct head-to-head comparison of AOD9604 and intact hGH in obese and lean mice confirmed that both compounds significantly reduced body weight gain in obese animals through increased fat oxidation and lipolysis stimulation but that AOD9604 achieved this without the hGH receptor binding, IGF-1 stimulation, hyperglycaemia, or reduced insulin secretion associated with full-length hGH treatment
3b) and TOM20 expression (Fig
However, despite growing understanding of the mechanisms of haemoglobin S polymerization and its effects on red blood cells, only two therapies for SCD hydroxyurea and l-glutamine are approved by the US Food and Drug Administration