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For adults over 65, no dose adjustment is required, but careful monitoring for adverse effects is prudent as older adults often have multiple comorbidities and medications that increase complication risk

While rare, these require immediate medical attention

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Licensed alternatives for weight management, including semaglutide (Wegovy) and liraglutide (Saxenda), are available through regulated NHS and private pathways following NICE appraisal

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Citation60,Citation66 Thus, it is possible that differences observed between subclasses are largely a consequence of changing the protein sequence