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21 Remarkably, even in HF-free patients with morbid obesity, cardiac abnormalities can be seen that are consistent with left ventricular (LV) remodelling and dysfunction, including greater LV mass, LV diastolic dysfunction and elevated LV filling pressure

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The reductions were dose-dependent: 4.9% with the 0.5mg dose, 15.2% with 4mg, 26.1% with 8mg, and 23.2% with 12mg

Jones, R