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The glucagon-like peptide 1 analogue Exendin-4 attenuates the nicotine-induced locomotor stimulation, accumbal dopamine release, conditioned place preference as well as the expression of locomotor sensitization in mice

Symptoms include: Diarrhea (typically watery but not bloody) Low-grade fever Nausea Occasional muscle aches or headache Stomach cramps and pain Vomiting The vomiting and diarrhea are the largest concerns, as patients can quickly become dehydrated

This method first creates smaller peptide fragments through the more controlled Solid-Phase Peptide Synthesis (SPPS)

Exp Clin Endocrinol Diabetes 114 , 417423, (2006)

Studies involving MK-677 typically include glucose metabolism monitoring as part of the safety assessment

In the first case (Fig