Notably, ammonia is simultaneously generated as a byproduct of glutamine deamination
(Elsevier, 2016)
Furthermore, a comprehensive review published in the Journal of Translational Medicine proposed a unifying model for ME/CFS and Long COVID, highlighting how viral infections (like SARS-CoV-2 or Epstein-Barr Virus) trigger a cascade of immune exhaustion, micro-clotting, and severe oxidative stress
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However, the enzyme can, under certain conditions, also inactivate cortisol and corticosterone by catalyzing the oxidation reactions converting cortisol to cortisone and corticosterone to 11-dehydrocorticosterone