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Competing interests: Authors Doyle, Kavanagh, Schrettl, Carberry and Haas are co-inventors on a patent application derived, in part, from the work presented in this manuscript

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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion

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5 Conclusion and prospect In conclusion, this review underscores the revolutionary potential of DDSs in transforming gout and hyperuricemia management through enhanced precision, efficacy, and patient compliance