surmount studies tirzepatide SURMOUNT-1 (NEJM 2022) tested — a dual GIP/GLP-1 receptor agonist — in 2,539 adults with obesity and achieved up to 20.9% mean weight loss at the highest dose. 57% of participants Weight reduction with different doses

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Selenium and prostate cancer: analysis of individual participant data from fifteen prospective studies

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CAPE blocks IKK phosphorylation, preventing NF-B nuclear translocation and cytokine expression (100)

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In the Phase 2 T2D cohort, this was offset by GLP-1/GIP-mediated insulin secretion, but close monitoring of fasting glucose during titration seems warranted